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  丁显廷

  yd12300云顶线路特聘教授、博士生导师，个性化医学研究院常务副院长、yd12300云顶线路分子与纳米医学平台主任。国家级科技创新领军人才、国家海外高层次人才、国家优秀青年科学基金、国家重点实验室PI、求是基金会“求是杰出青年学者奖”、广慈基金会“转化医学创新奖”、唐仲英基金会“仲英青年学者”、中国抗癌协会青年科技奖、上海市“曙光计划”学者、上海市科协“飞翔计划”学者、上海市优秀党外双创人才、yd12300云顶线路“凯原十佳教师“、世界经济论坛（World Economic Forum, WEF）青年科学家、世界顶尖科学家论坛（World Laureates Forum, WLF）青年科学家、美国南加州中华科学家工程师协会青年科学家、微纳系统与工程(Microsystems & Nanoengineering, MINE) Young Scientist Award、国际实验室自动化与筛查协会(Society for Laboratory Automatiom and Screening, SLAS) Tony B. Academic Award、iCANX Young Scientist Award。

  
  

          担任比尔.盖茨基金会(Bill & Melinda Gates Foundation)国际重大专项负责人、国家”重大新药创制“科技重大专项负责人、国家重点研发计划”生物安全技术“专项负责人、科技部APEC国际合作项目负责人、军委科技委国防创新特区第一批启动项目负责人、国家重点研发计划”前沿和共性技术创新“课题负责人、国家“艾滋病和病毒性肝炎等重大传染病防治”重大科技专项课题负责人、国际人类表型组计划课题负责人、上海市科技创新行动计划负责人、国家自然基金项目负责人等。

  
  

          担任6个国际SCI期刊的编委会成员，已发表包括Nature, Science Advances, Genome Biology, Advanced Materials, Angew Chemie, Nature Communications, PNAS, Nature Protocols, ACS Nano在内的国际期刊论文150余篇，申请国内外发明专利70余项。

  
  

          生物医学研究中，我们往往需要面对微量生物样本，甚至单细胞尺度上，实现与疾病相关的 1）蛋白质新靶点的发现；2）靶点蛋白相互作用网络的建立；3）超微量靶点蛋白的精准检测。这三个方面是全球普遍的挑战。课题组主要科研方向，面向国防安全和临床应用，开发基于痕量生物样本的个体化诊疗技术 ：1．痕量临床样本(单细胞)蛋白检验新原理和新技术；2.痕量临床样本（单细胞）蛋白检验新装置的集成化和微型化；3. 基于痕量临床样本的个体化药物敏感性检测新技术。

  
  

民盟中央委员；民盟上海市委员；民盟yd12300云顶线路副主委；上海市徐汇区政协委员。

中央JW科技委GF科技创新特区变革性交叉科学技术领域专家组专家委员、中国妇幼保健协会青年工作委员会医教研产一体化协作组副组长、全国肿瘤人工智能专业委员会委员、全国发酵工程技术工作委员会智能制造专业委员会委员、全国卫生产业协会实验医学专家委员会青年委员会委员、世界华人医师协会前沿科技与临床转化专业委员会委员、上海市免疫学会免疫遗传专业委员会常务委员、上海市药学会药物治疗专业委员会委员、上海医学会神经免疫学会委员、中国医药生物技术技术协会生物安全专业委员会委员。

担任法国国家科研署（ANR）国际通讯评审、澳大利亚国立健康与医学研究理事会（NHMRC）国际通讯评审、以色列科技部（MOST Israel）国际通讯评审、波兰国家科学中心（NCN）国际通讯评审、塞尔维亚科学基金会（Science Fund of the Republic of Serbia）、UK Pancreatic Cancer Research Fund (英国慈善科研机构)、Bill & Melinda Gates Foundation（美国慈善科研机构）国际通讯评审。

1. 单细胞蛋白组学技术、组学大数据人工智能建模

2. 体外诊断，生物传感器，微流控芯片技术

3. 痕量功能蛋白质富集、捕获、成像的纳米材料

实验室主页 ： http://www.dinglab.com.cn/

1. Jingqi Dang, Hongxia Li, Lulu Zhang, Sijie Li, Ting Zhang, Shiyi Huang, Yiyang Li, Chengjie Huang, Yuqing Ke, Guangxia Shen*, Xiao Zhi* and Xianting Ding*, New Structure Mass Tag based on Ab functionalized Zr-NMOF in Mass Cytometry for Multiparameter and Sensitive Single-Cell Biomarker Interrogating, Advanced Materials, 2021, 202008297

2. Shanhe Li#, Ze Wen, Behafarid Ghalandari, Tianhao Zhou, Antony R. Warden, Ting Zhang, Peng Dai, Youyi Yu, Wenke Guo, Mofang Liu, Haiyang Xie*, and Xianting Ding*, Single-cell transfection analysis chip enables high-throughput screening and accurate profiling of exogenous gene expression in single host cells, Advanced Materials, 2021, 2101108

3. Sijia Yan#, Khan Zara Ahmad, Sijie Li, Antony R. Warden, Jing Su, Yu Zhang, Youyi Yu, Xiao Zhi, Xianting Ding*, Precoated antibody proximity extension-enhanced biomarker (PROPER) assay enables trace protein detection with single-digit accuracy, Biosensors & Bioelectronics, 2021, 183:113211

4.Sijie Li#, Shiyi Huang, Yuqing Ke, Hongjun Chen, Jingqi Dang, Chengjie Huang, Wenjia Liu, Daxiang Cui, Jinglin Wang, Xiao Zhi*, Xianting Ding*, A HiPAD Integrated with rGO/MWCNTs Nano-Circuit Heater for Visual Point-of-Care Testing of SARS-CoV-2, Advanced Functional Materials, 2021, 2100801

5.Sijia Yan#, Khan Zara Ahmad, Antony R. Warden, Yuqing Ke, Nokuzola Maboyi, Xiao Zhi, Xianting Ding*. One-pot pre-coated interface proximity extension assay for ultrasensitive co-detection of anti-SARS-CoV-2 antibodies and viral RNA, Biosensors & Bioelectronics, 2021, 193 (2021) 113535

6.Yuqing Ke#, Shiyi Huang, Behafarid Ghalandari, Sijie Li, Antony R Warden, Jingqi Dang, Lin Kang, Yu Zhang, Yunqing Wang, Yiqing Sun, Jinglin Wang, Daxiang Cui , Xiao Zhi*, Xianting Ding*, Hairpin-spacer crRNA enhanced CRISPR/Cas13a system promotes the specificity of single nucleotide polymorphisms (SNPs) identification, Advanced Science, 2021, 2003611 

7.Ting Zhang#, Antony R. Warden, Yiyang Li, and Xianting Ding*, Progress and applications of mass cytometry in sketching immune landscapes, Clinical and Translational Medicine (CTM), 2020, 10(6)

8.Ting Zhang, Shanhe Li, Antony R. Warden, Behafarid Ghalandari, Hongxia Li, Xiao Zhi, Haiyang Xie*, and Xianting Ding*, A Photoclick Hydrogel for Enhanced Single-cell Immunoblotting, Advanced Functional Materials, 2020, 10, 1002: 1910739

9.Youyi Yu, Jingqi Dang, Xiao Liu, Liping Wang, Shanhe Li, Ting Zhang, Xianting Ding*, Metal-labeled Aptamers as Novel nanoprobes for Imaging Mass Cytometry Analysis, Analytical Chemistry, 2020, 92, 9, 6312-6320

10. Yu Zhang#, Antony R. Warden, Khan Zara Ahmad, Yanlei Liu, Xijun He, Minqiao Zheng, Xinlong Huo, Xiao Zhi, Yuqing Ke, Hongxia Li, Sijia Yan, Wenqiong Su, Deng Cai, Xianting Ding*. Single-Cell Microwell Platform Reveals Circulating Neural Cells as a Clinical Indicator for Patients with Blood-Brain Barrier Breakdown, Research, 2021: 9873545

11.Xiao Liu#, Weichen Song#, Brandon Yi-ning Wong, Ting Zhang, Shunying Yu, Guan Ning Lin*, Xianting Ding*, A comparison framework and guideline of clustering methods for mass cytometry data, Genome Biology, 2019, (2019) 20:297

12. Yilin Cai#, Shiyi Huang#, Zhinan Zhang*, Jiazheng Zhang, Xingyue Zhu, Xiaoxiang Chen, Xianting Ding*. Bioinspired Rotation Microneedles for Accurate Transdermal Positioning and Ultra-Minimal-Invasive Biomarker Detection with Mechanical Robustness, Research, 2022, 2022(5):1-15

13. Hongxia Li#, Antony R. Warden, Jie He, Guangxia Shen*, Xianting Ding*. Expansion Microscopy with Nine-fold Swelling (NIFS) Hydrogel Permits Cellular Ultrastructure Imaging on Conventional Microscope, Science Advances,2022, abm4003

14. Xianting Ding*, Zach Njus, Taejoon Kong, Wenqiong Su, Chih-Ming Ho and Santosh Pandey*, Effective drug combination for Caenorhabditis elegans nematodes discovered by output-driven feedback system control technique, Science Advances, 2017,3(10):eaao1254

15. Lulu Zhang#, Xiao Liu#, Xiaoxiang Chen, Antony R Warden, Youyi Yu, Baozhen Huang, Xianting Ding*. SCANCell reveals diverse inter-cluster interaction patterns in systemic lupus erythematosus across the disease spectrum, Bioinformatics, 2021, Volume 38, Issue 5, Pages 1361–1368

16.Youyi Yu#, Xin Wang#, Xiaolong Jia, Lulu Zhang, Hongxia Li, Jie He, Guangxia Sheng*, Xianting Ding*. Aptamer Probes Labeled with Lanthanide-Doped Carbon Nanodots permit Dual-Modal Fluorescence and Mass Cytometric Imaging, Advanced Science, 2021, 2102812

17.Boqian Wang#, Antony R.Warden, Xianting Ding*. The Optimization of Combinatorial Drug Therapies: Strategies and Laboratorial Platforms, Drug Discovery Today, 2021, 26 (11), pp.2646-2659