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  徐宏

  徐宏，首席研究员，博士生导师。“长江学者奖励计划”特岗学者，上海市高等学校优秀青年教师。主要从事基于微纳技术的创新生物检测及其在重大疾病早筛、早诊的基础及应用研究。在体外诊断用高品质功能微球的创制具有较好的理论基础与产业化转化经验，并在此基础上发展出一系列以微纳技术为核心的生物检测创新方法。先后在JACS, Adv. Mater., ACS Nano, Adv. Funct. Mater., Nat. Commun, Small, Small Methods, Biosens Bioelectron. 等知名期刊上发表论文100余篇，申请或授权发明专利50多项，专利成果转化率大于70%。承担多项国家自然基金项目、科技部重点项目、上海市科委、教委科技创新项目、yd12300云顶线路医工交叉重大、重点课题以及多项重大横向课题的研究。科研成果荣获教育部技术发明一等奖、自然科学二等奖以及上海市技术发明二等奖。

  
  

• 具有精密表、微观结构的纳米功能复合材料的可控制备及其与生物分子相互作用机制研究；

• 基于纳米功能材料的超灵敏、快速、多指标生物检测新方法及其在临床诊断的应用基础研究

• 肿瘤、阿尔兹海默病等重大慢病的早筛、早诊与真实世界队列研究

1.      Weiyuan Lyu#, Jingwei Yi#, Qingsheng Guo, Yao Wang, Jiajie Zhang, Tong Sun, Haoji Ma, Tingting Tang, Xueling Quan, Hong Xu*, Feng Shen*, and Hongchen Gu, Multiplex Digital Immunoassays with Reduced Pre-partition Reaction via Massively Parallel Reagent Delivery on a Bead-Based SlipChip, ACS Nano, 2023, 17, 13, 12641–12651.

2.      Mengqiu Yan, Zhenzhen Zhao, Tao Wu, Tangyuheng Liu, Gaolian Xu*, Hong Xu*, and Binwu Ying*，Highly sensitive detection of complicated mutations of drug resistance in mycobacterium tuberculosis using a simple, accurate, rapid, and low-cost tailored-design competitive wild-type blocking assay, Small Methods, 2023, 2201322. 

3.      Gaolian Xu, Hao Yang, Jiani Qiu, Julien Reboud, Linqing Zhen, Wei Ren, Hong Xu*, Jonathan M. Cooper*, Hongchen Gu*, Sequence terminus dependent PCR for site-specific mutation and modification detection, Nature Communications, 2023, 14, 1169.

4.      Zhejia Gu, Tong Sun, Qingsheng Guo, Yao Wang, Yunfei Ge, Hongchen Gu, Gaolian Xu*, Hong Xu*, Bead-based multiplexed droplet digital polymerase chain reaction in a single tube using universal sequences: an ultrasensitive, cross-reaction-free, and high-throughput strategy, ACS Sensors, 2022, 7, 2759−2766. 

5.      Feiyang Ou#, Danyun Lai #, Xiaojun Kuang, Ping He, Yang Li, He-wei Jiang, Wei Liu, Hongping Wei, Hongchen Gu, Yuan qiao Ji, Hong Xu*, Sheng-ce Tao*, Ultrasensitive monitoring of SARS-CoV-2-specific antibody responses based on a digital approach reveals one week of IgG seroconversion, Biosensors and Bioelectronics, 2022, 217,114710. 

6.      Jingwei Yi, Zehang Gao, Qingsheng Guo, You Wu, Tong Sun, Yao Wang, Hongbo Zhou, Hongchen Gu, Jianlong Zhao, Hong Xu*, Multiplexed digital ELISA in picoliter droplets based on enzyme signal amplification block and precisely decoding strategy: A universal and practical biodetection platform, Sensors & Actuators: B. Chemical, 2022, 369, 132214. 

7.      Xiaoyu Yue, Xiaoxia Fang*, Tong Sun, Jingwei Yi, Xiaojun Kuang, Qingsheng Guo, Yao Wang, Hongchen Gu, Hong Xu*, Breaking through the Poisson Distribution: A compact high-efficiency droplet microfluidic system for single-bead encapsulation and digital immunoassay detection, Biosensors and Bioelectronics, 2022, 211, 114384

8.      Xue Wu†, Zhenxu Xiao†, Jingwei Yi, Saineng Ding, Hongchen Gu, Wanqing Wu, Jianfeng Luo, Xiaoniu Liang, Li Zheng, Hong Xu*, Qianhua Zhao*, and Ding Ding, Development of a plasma biomarker diagnostic model incorporating ultrasensitive digital immunoassay as a screening strategy for Alzheimer disease in a chinese population, Clinical Chemistry, 2021, 67, 1628-1639.

9.      Yao Wang, Cang Chen, Jing He, Yimei Cao, Xiaoxia Fang, Xiaomei Chi, Jingwei Yi, Jiancong Wu, Qingsheng Guo, Hajar Masoomi, Chongzhao Wu, Jian Ye, Hongchen Gu, Hong Xu*, Precisely encoded barcodes through the structure-fluorescence combinational strategy: A flexible, robust, and versatile multiplexed biodetection platform with ultrahigh encoding capacities, Small, 2021, 2100315.

10.   Zhenxu Xiao, Xue Wu, Wanqing Wu, Jingwei Yi, Xiaoniu Liang, Saineng Ding, Li Zheng, Jianfeng Luo, Hongchen Gu, Qianhua Zhao*, Hong Xu* and Ding Ding, Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer’s disease, Alzheimer's Research & Therapy, 2021, 13:123. 

11.   Xiaoxia Fang, Cang Chen, Bing Liu, Fenglin Hu, Hongchen Gu*, Hong Xu*, A magnetic beads-mediated selective adsorption strategy (MagExo) for extracellular vesicles separation and purification, Acta Biomaterialia, 2021, 124, 336-347.  

12.   Sitong Xu, Jiancong Wu, Cang Chen, Jiayu Zhang, Hongchen Gu, Yao Wang*, Hong Xu*, A non-isolated and high-throughput digital biodetection method via the “sphere-labeled-sphere” strategy, Sensors & Actuators: B. Chemical, 2021, 337, 129794. 

13.   Zehang Gao, Jingwei Yi, Jianlong Zhao, Hongchen Gu, Hongbo Zhou*, Hong Xu*, Droplets isolated array: A universal platform of delaying molecule cross-contamination between microdroplets for digital enzyme-based immunoassay, Sensors & Actuators: B. Chemical, 2020, 324, 128716.  

14.   Qingsheng Guo, Yao Wang, Cang Chen, Dan Wei, Jianping Fu, Hong Xu*, Hongchen Gu*, Multiplexed luminescence oxygen channeling immunoassay based on dual-functional barcodes with a Host–Guest structure: A facile and robust suspension array platform, Small, 2020, 16, 1907521. 

15.   Zhejia Gu, Simin Zhao, Gaolian Xu, Cang Chen, Yao Wang, Hongchen Gu, Yi Sun*, Hong Xu*, Solid-phase PCR based on thermostable, encoded magnetic microspheres for simple, highly sensitive and multiplexed nucleic acid detection, Sensors and Actuators B: Chemical, 2019, 298, 126953.  

16.   Fenglin Hu, Kaimin Chen, Hong Xu*, Hongchen Gu*, Design and preparation of bi-functionalized short-chain modified zwitterionic nanoparticles, Acta Biomaterialia, 2018, 72, 239–247.   

17.   Si Lu, Ding Shengzi Zhang, Dan Wei, Ye Lin, Shunjia Zhang, Hao He, Xunbin Wei, Hongchen Gu, Hong Xu*, Three-Dimensional barcodes with ultrahigh encoding capacities: A flexible, accurate, and reproducible encoding strategy for suspension arrays, Chemistry of Materials, 2017, 29, 10398−10408. 

18.   Ding Sheng-zi Zhang, Yang Jiang, Haiou Yang, Youjie Zhu, Shunjia Zhang, Ying Zhu,Dan Wei1, Ye Lin, PingPing Wang, Qihua Fu, Hong Xu*, Hongchen Gu*, Dual-Encoded microbeads through a Host-Guest structure: enormous, flexible and accurate barcodes for multiplexed assays, Advanced Functional Materials, 2016, 26, 6146-6157.  

19.   Peirui Wang, Ping Xu, Pingping Wang, Lingling Deng, Hongchen Gu, Hong Xu*, Improvement of protein immobilization and bioactivity of magnetic carriers using a brushed Beads-on-Beads structure, ACS Applied Materials & Interfaces, 2015, 7, 24390−24395. 

20.   Zhenyuan Qu, Hong Xu*, Hongchen Gu*, Synthesis and biomedical applications of poly((meth)acrylic acid) brushes, ACS Applied Materials & Interfaces, 2015, 14537–14551.   

21.   Zhenyuan Qu, Hong Xu*, Kaimin Chen, Hongchen Gu*, Ultrasensitive ELISA using enzyme-loaded nanospherical brushes as labels, Analytical Chemistry, 2014, 86, 9367-9371.

22.   Hong Xu, Longlan Cui, Naihu Tong, and Hongchen Gu, Development of high magnetization Fe3O4/Polystyrene/Silica nanospheres via combined Miniemulsion/Emulsion polymerization, Journal of The American Chemical Society, 2006,128, 15582-15583.